Description

5-Amino-3,7-Dimethyl Xanthine-D6 is a deuterated analog of a key xanthine derivative, serving as a critical stable isotope-labeled internal standard for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug development and bioanalytical research.

Application

• Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for quantitative analysis.
• Critical component in pharmacokinetic (PK) and bioequivalence studies to track the metabolism and clearance of parent xanthine compounds.
• Enables precise metabolite profiling and identification in drug metabolism and disposition (DMPK) research.
• Supports method development and validation in clinical and forensic toxicology laboratories for accurate substance measurement.
• Used in academic and industrial research exploring adenosine receptor antagonists and phosphodiesterase (PDE) inhibitors.
• Facilitates quality control and assurance in the production of high-purity active pharmaceutical ingredients (APIs) and reference materials.

Basic Information

Product Name	5-Amino-3,7-Dimethyl Xanthine-D6
CAS No.	1185126-58-2
Molecular Formula	C7H3D6N5O2
Molecular Weight	197.21 g/mol
Synonyms	5-Amino-3,7-dimethyl-1H-purine-2,6-dione-d6; 5-Aminotheophylline-d6; 5-Amino-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine-d6; 5-Amino-1,3-dimethylxanthine-d6; 5-AT-d6; AMDX-d6; [2H6]-5-Amino-3,7-dimethylxanthine; Deuterated 5-Aminotheophylline
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-3,7-Dimethyl Xanthine-D6 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting requirements of analytical reference standards. Comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are provided to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.