Description

Diphenyl 4-(4-Fluorophenyl)-6-Isopropyl-2-(n-Methylmethylsulfonyl)Amino-Pyrimidin-5-Yl -Methyl]Phosphine Oxide-D6 is a deuterated isotopologue of a complex heterocyclic phosphine oxide compound, serving as a critical advanced intermediate for pharmaceutical research and development. Its primary value lies in enabling sophisticated metabolic, pharmacokinetic, and mechanistic studies through the use of stable isotope labeling. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly those developing novel kinase inhibitors or other targeted small-molecule therapies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of deuterated drug candidates, enhancing metabolic stability and enabling drug discovery programs.
• Metabolic Studies: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for accurate quantification and metabolite identification.
• Mechanistic Research: Facilitates reaction pathway analysis and degradation studies in medicinal chemistry due to its isotopic label.
• Agrochemical R&D: Potential intermediate in the development of novel, isotopically labeled pesticides or herbicides for environmental fate studies.
• Biochemical Probes: Can be utilized to create labeled probes for studying enzyme binding and inhibition mechanisms.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development and validation in regulatory submissions.

Basic Information

Product Name	Diphenyl 4-(4-Fluorophenyl)-6-Isopropyl-2-(n-Methylmethylsulfonyl)Amino-Pyrimidin-5-Yl -Methyl]Phosphine Oxide-D6
CAS No.	1185122-39-7
Molecular Formula	C28H23D6FN3O3PS
Molecular Weight	Contact for details
Synonyms	B-Raf Inhibitor Deuterated Intermediate; (5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropyl-2-((N-methylmethylsulfonamido)pyrimidine-d6; PLX4720-d6 Derivative; Vemurafenib Related Compound-d6; RAF Kinase Inhibitor Deuterated Analog; 5-[(Diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-[[(methylsulfonyl)methylamino]-d6-pyrimidine; [5-[(Diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-propan-2-yl-2-(N-methylmethanesulfonamido)pyrimidine-d6]
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch undergoes comprehensive analysis including NMR (¹H, ¹³C, ³¹P) for structural and isotopic confirmation, HPLC for chemical purity, and LC-MS to verify isotopic enrichment. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is moisture-sensitive; the container should be allowed to reach room temperature before opening to prevent condensation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, LC-MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.