Description

2-Chloromethyl-3,4-Dimethoxypyridine-D7, Hydrochloride is a deuterium-labeled derivative of a key pyridine-based building block, essential for advanced research and development. This compound is specifically valued for its role in creating isotopically labeled molecules for pharmacokinetic and metabolic studies, providing critical data with high precision. It is primarily utilized by pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) engaged in drug discovery and development.

Application

• Deuterated Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in bioanalytical method development for accurate drug metabolite quantification.
• Pharmaceutical Intermediate: Acts as a key synthetic precursor in the development of novel, isotopically labeled active pharmaceutical ingredients (APIs).
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to trace and elucidate drug metabolism and biotransformation pathways.
• Stable Isotope Labeling: Enables the synthesis of deuterium-labeled analogs of drug candidates for use in absorption, distribution, metabolism, and excretion (ADME) studies.
• Analytical Research: Employed in high-end analytical chemistry for method validation and ensuring regulatory compliance in drug testing.

Basic Information

Item	Details
Product Name	2-Chloromethyl-3,4-Dimethoxypyridine-D7, Hydrochloride
CAS No.	1185116-63-5
Molecular Formula	C9H5D7ClNO2 • HCl
Molecular Weight	254.16 g/mol (approx.)
Synonyms	3,4-Dimethoxy-2-(chloromethyl)pyridine-d7 hydrochloride; 2-(Chloromethyl)-3,4-dimethoxypyridine-d7 hydrochloride; Deuterated 2-Chloromethyl-3,4-dimethoxypyridine HCl; (3,4-Dimethoxypyridin-2-yl)methyl-d7 chloride hydrochloride; Perdeuterated 2-Chloromethyl-3,4-dimethoxypyridine hydrochloride; Pyridine-d7, 2-(chloromethyl)-3,4-dimethoxy-, hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-Chloromethyl-3,4-Dimethoxypyridine-D7, Hydrochloride is produced and tested under strict quality management protocols to ensure the highest standards of isotopic purity and chemical integrity, which are paramount for research applications. Our quality assurance includes comprehensive analytical testing, and a detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as chemical purity, isotopic enrichment (D7), and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D7, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.