Description

1-Bromo-2-Fluorocyclopropane is a versatile halogenated cyclopropane building block of significant interest in advanced organic synthesis. Its unique strained-ring structure, functionalized with both bromine and fluorine atoms, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, fluorination chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those incorporating fluorinated cyclopropane motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the fluorocyclopropane unit can impart unique biological activity.
• Fluorination Chemistry: Serves as a valuable reagent for introducing the cyclopropane ring and fluorine atom into target molecules via cross-coupling or substitution reactions.
• Material Science Research: Employed in the development of specialty polymers and advanced materials that require halogenated cyclic components.
• Medicinal Chemistry & SAR Studies: Utilized to explore structure-activity relationships by incorporating the strained, fluorinated three-membered ring into lead compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and proprietary intermediates.

Basic Information

Product Name	1-Bromo-2-Fluorocyclopropane
CAS No.	1185112-51-9
Molecular Formula	C3H4BrF
Molecular Weight	138.97 g/mol
Synonyms	2-Fluoro-1-bromocyclopropane; 1-Bromo-2-fluorocyclopropane; Bromofluorocyclopropane; (1-Bromo-2-fluoranyl)cyclopropane; Cyclopropane, 1-bromo-2-fluoro-; 1185112-51-9
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluorocyclopropane is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed and handle in a fume hood. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density	~1.7 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.