Description

Imidazol-1-Yl-Acetic Acid-D2 Hydrochloride is a deuterated derivative of imidazol-1-yl-acetic acid hydrochloride, where two hydrogen atoms are replaced by deuterium, making it a valuable stable isotope-labeled compound. This deuteration is critical for enhancing analytical precision in spectroscopic and mass spectrometric studies by reducing signal interference. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical sectors for use as an internal standard, a tracer in metabolic studies, and a building block in the synthesis of deuterated active pharmaceutical ingredients (APIs).

Application

• As a stable isotope-labeled internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical methods like LC-MS/MS.
• As a metabolic tracer in drug discovery and development to study the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• As a key deuterated synthetic intermediate in the research and production of novel deuterated drugs, where deuterium incorporation can improve pharmacokinetic profiles.
• In NMR spectroscopy as a tool for mechanistic studies and structural elucidation, leveraging the distinct magnetic properties of deuterium.
• For use in academic and industrial research focused on isotopically labeled compounds, chemical biology, and proteomics.

Basic Information

Product Name	Imidazol-1-Yl-Acetic Acid-D2 Hydrochloride
CAS No.	1185102-88-8
Molecular Formula	C5H5D2ClN2O2
Molecular Weight	176.60 g/mol (for monoisotopic mass)
Synonyms	1H-Imidazol-1-ylacetic-2,2-d2 acid hydrochloride; (Imidazol-1-yl)-Acetic-2,2-d2 Acid Hydrochloride; 2-(1H-Imidazol-1-yl)acetic-2,2-d2 acid hydrochloride; Imidazolylacetic Acid-d2 HCl; Deuterated Imidazolyl Acetic Acid Hydrochloride; 1-Carboxymethylimidazole-d2 hydrochloride; (1-Imidazolyl)acetic-2,2-d2 Acid Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Imidazol-1-Yl-Acetic Acid-D2 Hydrochloride is produced and analyzed under strict quality protocols to ensure high isotopic purity and chemical integrity, essential for research and regulatory submissions. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) providing detailed specifications for parameters such as chemical purity, isotopic enrichment (D%), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under inert atmosphere is recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.