Description

Apafant-D8 is a deuterated analog of the potent and selective platelet-activating factor (PAF) receptor antagonist, Apafant. This stable isotope-labeled compound is essential for advanced analytical and research applications where precise quantification and metabolic pathway tracing are required. It serves as a critical internal standard in LC-MS/MS and GC-MS analysis for pharmacokinetic, bioavailability, and drug metabolism studies. Researchers and analytical laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors rely on its high isotopic purity and chemical stability for accurate and reliable data.

Application

• Used as a stable isotope-labeled internal standard for the quantitative bioanalysis of Apafant in biological matrices via LC-MS/MS.
• Critical for conducting pharmacokinetic (PK) and pharmacodynamic (PD) studies to understand drug absorption, distribution, metabolism, and excretion (ADME).
• Facilitates drug metabolism and metabolite identification studies in pharmaceutical R&D.
• Enables precise quantification in clinical trial sample analysis for regulatory submissions.
• Supports forensic and anti-doping analysis where accurate measurement of target analytes is paramount.
• Applied in academic research investigating the role of PAF in inflammatory and allergic pathways.

Basic Information

Product Name	Apafant-D8
CAS No.	1185101-22-7
Molecular Formula	C26H25D8N5O3
Molecular Weight	Contact for details
Synonyms	4-(2-Chlorophenyl)-9-methyl-2-[3-(morpholin-4-yl)-3-oxopropyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-d8; WEB 2086-d8; Apafant (D8); Deuterated Apafant; Apafant Internal Standard; PAF Receptor Antagonist-d8; (RS)-Apafant-D8
EINECS	Contact for details

Quality Control

Every batch of Apafant-D8 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment. Our quality protocols are designed to meet the stringent requirements of GMP/GLP-compliant laboratories and global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.