Description

n-(2-Methylbenzoyl)Glycine-2,2-D2 is a deuterated derivative of the organic compound N-(o-toluoyl)glycine, where two hydrogen atoms at the 2-position of the glycine moiety are replaced with deuterium. This isotopic labeling makes it a critical tool in pharmaceutical research and development, particularly for use as an internal standard in quantitative mass spectrometry. It is primarily utilized by analytical chemists and researchers in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require high-purity, stable isotope-labeled compounds for method development, drug metabolism, and pharmacokinetic (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Essential for accurate quantification in bioanalytical methods due to its nearly identical chemical properties to the non-deuterated analyte.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracing and studying the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• Biomarker Research: Enables precise measurement of endogenous metabolites in complex biological matrices for diagnostic and research purposes.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during drug development.
• Stable Isotope Labeling: Serves as a building block or reference material in the synthesis of more complex deuterated molecules for various research applications.

Basic Information

Product Name	n-(2-Methylbenzoyl)Glycine-2,2-D2
CAS No.	1185100-98-4
Molecular Formula	C10H9D2NO3
Molecular Weight	195.22 g/mol (approx.)
Synonyms	N-(o-Toluoyl)glycine-2,2-d2; 2-[(2-Methylbenzoyl)amino]acetic-2,2-d2 acid; Hippuric-2,2-d2 acid, 2'-methyl-; 2-Methylhippuric-2,2-d2 acid; Deuterated o-Methylhippuric Acid; (2-Methylbenzamido)acetic-2,2-d2 acid; N-(2-Methylbenzoyl)glycine-d2 (2,2); CAS 1185100-98-4
EINECS	Contact for details

Quality Control

Our n-(2-Methylbenzoyl)Glycine-2,2-D2 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by NMR (¹H, ¹³C) and mass spectrometry to confirm structure and deuterium incorporation. We provide comprehensive Certificates of Analysis (COA) detailing assay purity (typically by HPLC), isotopic enrichment, and identification. Our quality system supports compliance with relevant standards for research and development materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.