Description

9-[[2-Benzyloxy-1-(Benzyloxymethyl)-Ethoxy]-Methyl]Guanine-D5 is a deuterated analog of a key guanine derivative, serving as a critical stable isotope-labeled intermediate in advanced pharmaceutical research and development. This compound matters for its role in enabling precise metabolic and pharmacokinetic studies through mass spectrometry, providing essential data for drug discovery programs. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) focused on antiviral and anticancer therapeutics.

Application

• As a stable isotope-labeled internal standard for the quantitative bioanalysis of antiviral compounds via LC-MS/MS.
• In the synthesis and development of deuterated drug candidates, where the D5-label improves metabolic stability.
• For pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies in preclinical and clinical research.
• As a high-purity reference standard in quality control laboratories for method development and validation.
• In proteomics and metabolomics research as a tool compound for pathway analysis.
• For academic research investigating nucleoside analog chemistry and mechanisms of action.

Basic Information

Product Name	9-[[2-Benzyloxy-1-(Benzyloxymethyl)-Ethoxy]-Methyl]Guanine-D5
CAS No.	1185100-63-3
Molecular Formula	C22H20D5N5O3
Molecular Weight	~403.49 g/mol
Synonyms	9-((2-(Benzyloxy)-1-((benzyloxy)methyl)ethoxy)methyl)-2-amino-1,9-dihydro-6H-purin-6-one-d5; Deuterated Ganciclovir Benzyloxybenzyl Derivative; 9-[[2-(Phenylmethoxy)-1-[(phenylmethoxy)methyl]ethoxy]methyl]-1,9-dihydro-6H-purin-6-one-d5; 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one Benzyl Ether-d5; Ganciclovir Dibenzyl Ether-d5; Bn-Ganciclovir-d5; Deuterated Nucleoside Intermediate; (2-((2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-(benzyloxy)propyl)methyl benzyl ether-d5
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure isotopic purity and chemical identity. Certificates of Analysis (COA) are provided with each shipment, detailing assay, isotopic enrichment (D5), and impurity profiles. We support compliance with ICH guidelines for impurities and can supply materials suitable for use under GMP conditions for research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.