Description

1-(Chloromethyl)-7-Fluoro-3,4-Dihydroisoquinoline Hcl CAS NO 1185099-31-3 is a high-purity, functionalized isoquinoline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique molecular scaffold, which combines a reactive chloromethyl group with a fluorine substituent, enabling precise structural modifications for creating novel compounds. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Chemical Biology Probe Synthesis: Employed to create tagged or fluorescently labeled molecules for studying biological pathways and target engagement.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, including novel cyclization and cross-coupling reactions.

Basic Information

Product Name	1-(Chloromethyl)-7-Fluoro-3,4-Dihydroisoquinoline Hydrochloride
CAS No.	1185099-31-3
Molecular Formula	C11H12Cl2FN
Molecular Weight	248.12 g/mol
Synonyms	7-Fluoro-1-(chloromethyl)-3,4-dihydroisoquinoline hydrochloride; 1-(Chloromethyl)-7-fluoro-3,4-dihydroisoquinoline hydrochloride; 7-Fluoro-1-(chloromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1185099-31-3; 7-Fluoro-1-chloromethyl-3,4-dihydroisoquinoline HCl; 1-Chloromethyl-7-fluoro-3,4-dihydroisoquinoline HCl salt
EINECS	Contact for details

Quality Control

Our production of 1-(Chloromethyl)-7-Fluoro-3,4-Dihydroisoquinoline Hcl adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical R&D and scale-up processes. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.