Description

6-[2,2,3,3,5,5,6,6-Octadeuterio-4-[2-(2-Hydroxyethoxy)Ethyl]Piperazin-1-Yl]Benzo[B][1,4]Benzothiazepin-2-Ol is a deuterated derivative of a benzothiazepine-based compound, serving as a critical stable isotope-labeled internal standard for precise analytical quantification. Its primary value lies in enabling highly accurate and reliable mass spectrometry measurements by correcting for instrument variability and matrix effects. This compound is essential for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require the utmost precision in method development and bioanalytical studies.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled analog for the accurate quantification of its non-deuterated parent drug or metabolite in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Metabolite Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Critical for developing robust, sensitive, and reproducible analytical methods compliant with FDA, EMA, and ICH guidelines.
• Forensic Toxicology: Assists in the definitive identification and quantification of specific benzothiazepine-class compounds in forensic samples.
• Drug Impurity Profiling: Can be utilized in stability studies to monitor degradation products and ensure drug product purity.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike for this gold-standard technique, ensuring maximum accuracy in quantitative analysis.

Basic Information

Product Name	6-[2,2,3,3,5,5,6,6-Octadeuterio-4-[2-(2-Hydroxyethoxy)Ethyl]Piperazin-1-Yl]Benzo[B][1,4]Benzothiazepin-2-Ol
CAS No.	1185098-57-0
Molecular Formula	C23H22D8N3O3S
Molecular Weight	Contact for details
Synonyms	Deuterated Benzothiazepin-2-ol Derivative; 6-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]benzo[b][1,4]benzothiazepin-2-ol-d8; D8-Labeled Benzothiazepine Internal Standard; 6-(4-(2-(2-Hydroxyethoxy)ethyl)piperazin-1-yl)benzo[b][1,4]benzothiazepin-2-ol-d8; Stable Isotope-Labeled Benzothiazepine; CAS 1185098-57-0; Deuterated Piperazinyl Benzothiazepinol
EINECS	Contact for details

Quality Control

Every batch of this stable isotope-labeled compound is manufactured and analyzed under strict quality systems to ensure isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including HPLC, NMR, and Mass Spectrometry, to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing batch-specific results are provided and can be supplied to support GLP/GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.