Description

5-[1,1,2,3,3-Pentadeuterio-2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Naphthalen-1-Ol is a deuterated derivative of a naphthalene-based compound, designed for advanced research and development applications. This high-purity, isotopically labeled material is critical for studies requiring enhanced analytical sensitivity and metabolic stability, such as in pharmacokinetic and pharmacodynamic research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug discovery and development, particularly for investigating β-adrenergic receptor-related pathways.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the quantitative analysis of its non-deuterated counterpart in complex biological matrices using LC-MS/MS.
• Metabolic Pathway Tracing: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track and quantify drug metabolites with high precision due to its deuterium labels.
• Drug Discovery Research: Employed as a key intermediate or probe in the synthesis and biological evaluation of novel β-blocker or related therapeutic agents.
• Biochemical Assay Development: Acts as a ligand or tracer in the development of high-throughput screening assays for receptor binding studies.
• Academic & Institutional Research: Supports fundamental chemical and pharmacological research in universities and government labs.
• Stability-Indicating Method Development: Used to develop and validate analytical methods that can distinguish the parent compound from its degradation products.

Basic Information

Product Name	5-[1,1,2,3,3-Pentadeuterio-2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Naphthalen-1-Ol
CAS No.	1185084-01-8
Molecular Formula	C₁₈H₂₀D₅NO₃
Molecular Weight	~307.4 g/mol
Synonyms	Deuterated 1-Naphthol Propanolamine Derivative; 5-[(2-Hydroxy-3-[(1-methylethyl)amino]propoxy)-1,1,2,3,3-d5]-1-naphthalenol; 1-Naphthalenol, 5-[(2-hydroxy-3-[(1-methylethyl)amino]propoxy)-1,1,2,3,3-d5]-; Deuterated Nadolol Impurity/Intermediate; (RS)-5-[3-(tert-Butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydro-2,3-naphthalenediol-d5 (related); Isotopically Labeled β-Blocker Intermediate; [D5]-Labeled Naphthoxy Propanolamine.
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR, HPLC, and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment (D-content), and absence of critical impurities. Our quality systems support compliance with relevant guidelines for reference standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere (e.g., argon or nitrogen) to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.