Description

1-(4-Chlorophenyl)-2-[3-(5,6-Dihydrobenzo[B][1]Benzazepin-11-Yl)Propyl-(Trideuteriomethyl)Amino]Ethanone is a deuterated organic compound of significant interest in advanced pharmaceutical research and development. Its core value lies in its utility as a key intermediate or active pharmaceutical ingredient (API) precursor for creating novel therapeutic agents, particularly in the fields of neuroscience and psychiatry. This compound is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of deuterated drugs, where the incorporation of deuterium can enhance metabolic stability and improve pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of deuterated benzazepine-based active pharmaceutical ingredients (APIs).
• Deuterated Drug Development: Used in research programs aimed at creating new chemical entities (NCEs) with improved metabolic stability and reduced side-effect profiles.
• Neurological & Psychiatric Research: Acts as a precursor for compounds targeting central nervous system (CNS) disorders, such as depression, anxiety, or schizophrenia.
• Metabolic Studies: Employed as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) for accurate bioanalytical quantification.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead drug candidates.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	1-(4-Chlorophenyl)-2-[3-(5,6-Dihydrobenzo[B][1]Benzazepin-11-Yl)Propyl-(Trideuteriomethyl)Amino]Ethanone
CAS No.	1185083-78-6
Molecular Formula	C26H26D3ClN2O
Molecular Weight	423.99 g/mol (approx.)
Synonyms	1-(4-Chlorophenyl)-2-[[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl](trideuteriomethyl)amino]ethanone; 11-[3-[[(Trideuteriomethyl)amino]propyl]-5,6-dihydrobenzo[b][1]benzazepine-2-(4-chlorophenyl)ethanone; Deuterated Lofepramine Derivative; CD3-Labeled Benzazepine Ketone; (4-Chlorophenyl)-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-(trideuteriomethyl)amino]methanone; 1185083-78-6; Lofepramine-d3 derivative
EINECS	Contact for details

Quality Control

Our 1-(4-Chlorophenyl)-2-[3-(5,6-Dihydrobenzo[B][1]Benzazepin-11-Yl)Propyl-(Trideuteriomethyl)Amino]Ethanone is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic purity, and impurity profiles. We support development with custom purity grades and specifications tailored to your project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.