Description

Dehydro Indapamide-D3 is a high-purity, stable isotope-labeled analog of the active pharmaceutical ingredient Indapamide, specifically designed for use as an internal standard in quantitative analytical methods. This compound is critical for ensuring the accuracy, precision, and reliability of mass spectrometry-based analyses in pharmaceutical research and quality control. It is an essential tool for scientists and quality assurance professionals in pharmaceutical development, clinical research, and forensic toxicology laboratories who require definitive quantification of Indapamide and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of Indapamide in biological matrices (plasma, serum, urine) and pharmaceutical formulations using Liquid Chromatography-Tandem Mass Spectrometry.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical trials and preclinical research.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring Indapamide levels in patient samples to optimize dosing regimens.
• Metabolite Identification and Profiling: Aids in the identification and quantification of Indapamide metabolites during drug metabolism studies.
• Pharmaceutical Quality Control: Used in impurity profiling and assay validation to ensure the potency and purity of Indapamide drug products according to pharmacopeial standards (USP, EP).
• Forensic and Anti-Doping Analysis: Provides a reliable reference for the confirmatory analysis of Indapamide in forensic toxicology and sports doping control.

Basic Information

Product Name	Dehydro Indapamide-D3
CAS No.	1185057-48-0
Molecular Formula	C16H13D3ClN2O3S
Molecular Weight	~ 368.85 g/mol
Synonyms	4-Chloro-N-(2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide-D3; Indapamide-d3; 1-(4-Chloro-3-sulfamoylbenzamido)-2,3-dihydroindole-d3; 4-Chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-3-sulfamoylbenzamide-d3 (Deuterated); [2H3]-Indapamide; Deuterated Indapamide Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Dehydro Indapamide-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and isotopic enrichment. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from NMR (1H, 13C), Mass Spectrometry (MS), and High-Performance Liquid Chromatography (HPLC). We commit to supplying material that meets the stringent requirements for analytical reference standards in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); desiccate if necessary. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.