Description

Chlorpheniramine-D6See C424303 CAS NO 1185054-60-7 is a deuterium-labeled analog of the classic antihistamine, chlorpheniramine maleate. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is a critical material for pharmaceutical research and development, clinical laboratories, and forensic toxicology, where precise measurement of drug concentrations is paramount.

Application

• Internal Standard for LC-MS/MS: Primary application in bioanalytical method development and validation for pharmacokinetic and toxicokinetic studies.
• Pharmaceutical R&D: Used in drug metabolism and disposition (DMPK) studies to track and quantify the parent drug and metabolites in biological matrices.
• Clinical Research: Enables accurate therapeutic drug monitoring (TDM) and biomarker analysis in patient samples.
• Forensic Analysis: Provides definitive quantification in post-mortem and anti-doping testing for chlorpheniramine and related compounds.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring method compliance with FDA, EMA, and other regulatory guidelines.

Basic Information

Product Name	Chlorpheniramine-D6See C424303 CAS NO 1185054-60-7
CAS No.	1185054-60-7
Molecular Formula	C16H13D6ClN2
Molecular Weight	277.81 g/mol (approx.)
Synonyms	Chlorpheniramine-d6; Deuterated Chlorpheniramine; Chlorphenamine-d6; 2-[p-Chloro-α-(2-dimethylaminoethyl)benzyl]pyridine-d6; 3-(4-Chlorophenyl)-N,N-dimethyl-3-pyrid-2-yl-propylamine-d6; C424303; Chlorpheniramine Maleate-d6 (labeled form); (±)-Chlorpheniramine-d6
EINECS	Contact for details

Quality Control

Every batch of Chlorpheniramine-D6See C424303 is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (typically >98 atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality commitment ensures consistency and reliability for your most sensitive analytical applications, supporting compliance with GLP and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥98 atom % D
Chemical Purity	≥95%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.