Description

5-[2-Ethoxy-5-[4-(Trideuteriomethyl)Piperazin-1-Yl]Sulfonylphenyl]-3-Propyl-2,4-Dihydropyrazolo[4,3-D]Pyrimidin-7-One is a deuterated organic compound of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a key intermediate or reference standard for deuterated drug candidates, where the strategic incorporation of deuterium can enhance metabolic stability and pharmacokinetic profiles. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical industry focused on developing novel therapeutics, particularly in areas requiring precise isotopic labeling for drug discovery and bioanalytical studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of deuterated active pharmaceutical ingredients (APIs) targeting specific therapeutic pathways.
• Reference Standard: Used as an analytical standard in method development and validation for quantifying deuterated compounds in complex matrices via LC-MS or HPLC.
• Drug Discovery Research: Employed in medicinal chemistry programs to study the deuterium kinetic isotope effect (DKIE) on drug metabolism, potency, and safety.
• Metabolite Identification: Aids in the identification and characterization of metabolites in preclinical and clinical studies through isotopic tracing.
• Process Chemistry & Scale-up: Utilized in the development and optimization of scalable synthetic routes for deuterated pharmaceuticals.
• Academic & Contract Research: Supports fundamental research in universities and CROs (Contract Research Organizations) exploring novel heterocyclic and deuterated chemistry.

Basic Information

Product Name	5-[2-Ethoxy-5-[4-(Trideuteriomethyl)Piperazin-1-Yl]Sulfonylphenyl]-3-Propyl-2,4-Dihydropyrazolo[4,3-D]Pyrimidin-7-One
CAS No.	1185044-03-4
Molecular Formula	C22H27D3N6O4S
Molecular Weight	477.58 g/mol
Synonyms	5-[2-Ethoxy-5-[4-(Trideuteriomethyl)-1-piperazinyl]sulfonyl]phenyl]-3-propyl-1,4-dihydro-2H-pyrazolo[4,3-d]pyrimidin-7-one; Deuterated PDE5 Inhibitor Intermediate; CD3-Labeled Piperazine Derivative; 1185044-03-4; Tadalafil-d3 Related Compound; Deuterated Sulfonylphenyl Dihydropyrazolopyrimidinone; 3-Propyl-5-[2-ethoxy-5-(4-(trideuteriomethyl)piperazine-1-sulfonyl)phenyl]-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to a quality management system to ensure traceability and consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.