Description

Verapamil-D6, Hydrochloride is a deuterium-labeled internal standard of the calcium channel blocker Verapamil, essential for precise quantitative analysis in bioanalytical research. This high-purity, isotopically labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based assays, eliminating variability and improving data integrity. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and clinical trial sample analysis.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of Verapamil and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic (PK) and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism and Disposition Research: Facilitates the study of metabolic pathways and the identification of metabolites in in vitro and in vivo systems.
• Clinical Trial Support: Provides reliable quantification for therapeutic drug monitoring and compliance testing during clinical development phases.
• Forensic and Toxicology Analysis: Supports the accurate detection and measurement of Verapamil in forensic investigations and toxicological screenings.
• Method Development and Validation: Serves as a critical component in developing, optimizing, and validating robust analytical methods in regulated laboratories.

Basic Information

Product Name	Verapamil-D6, Hydrochloride
CAS No.	1185032-80-7
Molecular Formula	C27H32D6ClN2O4 • HCl
Molecular Weight	~ 507.1 g/mol
Synonyms	Verapamil-d6 HCl; (±)-Verapamil-d6 hydrochloride; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile-d6 hydrochloride; 2,3,4,5,6,6-Hexadeutero-verapamil hydrochloride; Isoptin-d6 HCl; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzenecetonitrile-d6 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Verapamil-D6, Hydrochloride is manufactured and tested under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed data on purity, isotopic purity (D-enrichment), and analytical results from techniques such as HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the product label or CoA. This compound is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.