Description

8-Fluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to the fluorine atom's ability to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Serves as a building block for developing novel pesticides and herbicides with enhanced efficacy.
• Chemical Biology: Employed in the synthesis of probes and tool compounds for studying biological pathways and target engagement.
• Academic Research: Utilized in universities and research institutes for methodological development in organic synthesis and heterocyclic chemistry.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	8-Fluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1185030-61-8
Molecular Formula	C9H11ClFN
Molecular Weight	187.64 g/mol
Synonyms	8-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 8-Fluoro-1,2,3,4-tetrahydroisoquinoline HCl; 8-Fluoro-THIQ hydrochloride; 8-Fluoro-3,4-dihydro-1H-isoquinoline hydrochloride; 8-Fluoro-1,2,3,4-tetrahydroisoquinoline monohydrochloride; 8-F-THIQ HCl; 8-Fluoro-1,2,3,4-tetrahydroisoquinoline, hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized and controlled using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, residual solvents, and related substances are available upon request. We adhere to cGMP principles for the manufacture of pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.