Description

Methyl 2-(4-Bromophenyl)-2,2-Di-(Methyl-D3)Acetate is a high-purity, deuterium-labeled organic compound, serving as a critical stable isotope-labeled intermediate for advanced research and development. Its core value lies in enabling precise metabolic and pharmacokinetic studies through mass spectrometry, providing superior analytical sensitivity and reliability. This compound is essential for pharmaceutical, agrochemical, and academic researchers focused on drug discovery, metabolite identification, and environmental fate analysis.

Application

• Pharmaceutical Research: As a stable isotope-labeled internal standard for the accurate quantification of active pharmaceutical ingredients (APIs) and their metabolites in LC-MS/MS bioanalysis.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies in preclinical and clinical research.
• Agrochemical Development: Used as a tracer in environmental fate studies to understand the degradation pathways and residue analysis of crop protection agents.
• Synthetic Chemistry: Acts as a key deuterated building block for the synthesis of more complex labeled target molecules in medicinal chemistry.
• Forensic and Clinical Toxicology: Provides a reliable reference standard for the detection and confirmation of specific compounds in complex biological matrices.
• Academic Research: Supports mechanistic studies in organic chemistry and biochemistry where isotopic labeling is required to elucidate reaction pathways.

Basic Information

Product Name	Methyl 2-(4-Bromophenyl)-2,2-Di-(Methyl-D3)Acetate
CAS No.	1185004-76-5
Molecular Formula	C11H10D3BrO2
Molecular Weight	260.15 g/mol
Synonyms	Methyl 2-(4-bromophenyl)-2,2-bis(methyl-d3)acetate; Methyl α,α-Bis(trideuteriomethyl)-4-bromobenzeneacetate; 2-(4-Bromophenyl)-2,2-bis(methyl-d3)acetic acid methyl ester; (4-Bromophenyl)bis(methyl-d3)acetic acid methyl ester; Methyl (4-bromophenyl)bis(trideuteriomethyl)acetate; Deuterated Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate; d3-Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate
EINECS	Contact for details

Quality Control

Our Methyl 2-(4-Bromophenyl)-2,2-Di-(Methyl-D3)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical purity, isotopic enrichment, and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and identity are provided with every shipment to support your compliance and research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.