Description

1-Methyl-D3-2-(4-Methylbenzoyl)Pyrrole is a deuterated pyrrole derivative, specifically a deuterated isotopologue of a key heterocyclic building block. This compound matters for its utility as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily needed by research and development laboratories in the pharmaceutical, agrochemical, and advanced material sectors for applications in drug metabolism and pharmacokinetics (DMPK) studies, impurity profiling, and tracer analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of its non-deuterated counterpart or related metabolites in complex biological matrices.
• Drug Metabolism Studies (DMPK): Used in pharmaceutical R&D to track the absorption, distribution, metabolism, and excretion (ADME) of drug candidates, leveraging the deuterium label for differentiation.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate quantitative analysis in environmental testing, food safety, and clinical diagnostics by correcting for sample preparation and instrument variability.
• Chemical Synthesis Intermediate: Acts as a specialized building block for the synthesis of more complex deuterated molecules for research purposes.
• Impurity Profiling and Characterization: Aids in the identification and quantification of process-related impurities or degradation products in active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Methyl-D3-2-(4-Methylbenzoyl)Pyrrole
CAS No.	1185001-74-4
Molecular Formula	C13H10D3NO
Molecular Weight	202.27 g/mol
Synonyms	1-(Trideuteriomethyl)-2-(4-methylbenzoyl)-1H-pyrrole; 2-(4-Methylbenzoyl)-1-(methyl-d3)-1H-pyrrole; Deuterated 1-Methyl-2-(p-toluoyl)pyrrole; [D3]-1-Methyl-2-(4-methylbenzoyl)pyrrole; 1-Methyl-d3-2-(p-toluoyl)pyrrole; Isotopologue of 1-Methyl-2-(4-methylbenzoyl)pyrrole; Stable Isotope Labeled Pyrrole Derivative
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality protocols to ensure the highest isotopic and chemical purity for demanding analytical applications. Each batch of 1-Methyl-D3-2-(4-Methylbenzoyl)Pyrrole is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to cGMP principles where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.