Description

Tolmetin-D3 is a stable isotope-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) Tolmetin, where three hydrogen atoms are replaced by deuterium. This compound is a critical analytical standard used for precise quantification and metabolic studies, ensuring accuracy and reliability in sensitive detection methods. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development, bioanalytical method validation, and pharmacokinetic research.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the accurate quantification of Tolmetin in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in metabolic stability studies, absorption, distribution, metabolism, and excretion (ADME) research to track and differentiate the parent drug from its metabolites.
• Bioanalytical Method Development and Validation: Essential for developing and validating robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Clinical and Pre-clinical Research: Enables precise measurement of drug concentrations in clinical trials and pre-clinical animal studies to establish safety and efficacy profiles.
• Forensic and Doping Analysis: Applied in forensic toxicology and anti-doping controls for the definitive identification and quantification of Tolmetin.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development in the manufacturing process of Tolmetin sodium or related formulations.

Basic Information

Product Name	Tolmetin-D3
CAS No.	1184998-16-0
Molecular Formula	C15H12D3NO3
Molecular Weight	264.31 g/mol (approximate)
Synonyms	1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid-d3; Deuterated Tolmetin; Tolmetin (methyl-d3); Tolmetin-d3; [2,3,4-2H3]Tolmetin; 2-[1-Methyl-5-(p-toluoyl)-1H-pyrrol-2-yl]acetic-2,3,4-d3 acid; Tolectin-d3 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of Tolmetin-D3 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use as a high-purity reference standard. Our quality commitment includes verification of isotopic purity (deuterium incorporation), chemical purity, and structural identity. Certificates of Analysis (COA) detailing batch-specific results from techniques like HPLC, NMR, and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity	≥98.0 atom % D (by MS)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.