Description

Hydroxybupropion-D6 is a deuterium-labeled internal standard of the major active metabolite of bupropion, specifically designed for use in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and precision in pharmacokinetic and bioanalytical studies, where reliable reference materials are critical. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and mass spectrometry-based assays.

Application

• Primary use as an internal standard for the quantification of hydroxybupropion in LC-MS/MS and GC-MS bioanalytical methods.
• Critical component in pharmacokinetic (PK) studies and drug metabolism research for bupropion and related formulations.
• Supporting clinical trial analysis to monitor metabolite levels in plasma, serum, or urine samples.
• Method development and validation in forensic toxicology and doping control laboratories.
• Quality control and assurance in the manufacturing of bupropion-based active pharmaceutical ingredients (APIs).
• Used as a reference material in stable isotope dilution analysis (SIDA) to achieve high analytical accuracy.

Basic Information

Product Name	Hydroxybupropion-D6
CAS No.	1184984-06-2
Molecular Formula	C13H12D6ClNO
Molecular Weight	245.78 g/mol
Synonyms	(2R,3R)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-(methyl-d3)oxazolidine-4-one-d3; (2R,3R)-Hydroxybupropion-d6; 2-Hydroxybupropion-D6; BW 306U-D6; (1RS,2RS)-2-(3-Chlorophenyl)-3,5,5-trimethyl-4,4-d2-morpholin-2-one-3,3,5-d3; Deuterated Hydroxybupropion; Hydroxybupropion Internal Standard
EINECS	Contact for details

Quality Control

Our Hydroxybupropion-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.