Description

3-(2-Chloroethyl-D4)-2-Methyl-9-(Benzyloxy)-4H-Pyrido[1,2A]Pyrimidin-4-One is a high-purity, deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled analog, which is critical for conducting precise pharmacokinetic, metabolic, and bioanalytical studies. This compound is primarily needed by R&D laboratories and pharmaceutical companies engaged in the development of novel therapeutics, where it serves as an essential tool for drug discovery and mechanism-of-action investigations.

Application

• Pharmaceutical Research & Development: Used as a deuterium-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of drug candidates and their metabolites.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for conducting absorption, distribution, metabolism, and excretion (ADME) studies to understand the fate of pharmaceutical compounds within biological systems.
• Bioanalytical Method Development: Serves as a critical reference standard for validating analytical methods, ensuring high accuracy, precision, and regulatory compliance in bioanalysis.
• Isotope Dilution Mass Spectrometry: Employed in quantitative proteomics and metabolomics research to achieve highly accurate measurements of biomolecules.
• Chemical Synthesis: Acts as a specialized building block for the synthesis of more complex deuterated molecules for research purposes.

Basic Information

Product Name	3-(2-Chloroethyl-D4)-2-Methyl-9-(Benzyloxy)-4H-Pyrido[1,2A]Pyrimidin-4-One
CAS No.	1184973-69-0
Molecular Formula	C18H15D4ClN2O2
Molecular Weight	334.83 g/mol (for deuterated form)
Synonyms	9-(Benzyloxy)-3-(2-chloroethyl-d4)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; Deuterated Pyridopyrimidinone Derivative; 3-(2-Chloroethyl-1,1,2,2-d4)-2-methyl-9-(phenylmethoxy)-4H-pyrido[1,2-a]pyrimidin-4-one; 1184973-69-0; (2-Chloroethyl-d4)-Labeled Pyridopyrimidinone; Benzyloxy Pyridopyrimidinone-d4; Stable Isotope-Labeled Intermediate; D4-Labeled Chloroethyl Pyridopyrimidinone
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Chloroethyl-D4)-2-Methyl-9-(Benzyloxy)-4H-Pyrido[1,2A]Pyrimidin-4-One is produced and tested under strict quality management systems. Our products undergo rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical purity, isotopic enrichment, and structural identity. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.