Description

3-(2,2-Difluoroethoxy)Benzyl Alcohol is a high-value fluorinated aromatic building block, essential for introducing the 2,2-difluoroethoxy pharmacophore into complex molecules. Its primary commercial value lies in enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This intermediate is critically needed by pharmaceutical R&D and process chemistry teams, as well as agrochemical and advanced material scientists, for the development of next-generation products.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of small molecule drugs, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoroethoxy group can improve lipophilicity and biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for fluorinated compounds used in electronic displays and organic light-emitting diodes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring fluorinated benzyl derivatives.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new fluorination strategies and structure-activity relationships.

Basic Information

Product Name	3-(2,2-Difluoroethoxy)Benzyl Alcohol
CAS No.	1184667-43-3
Molecular Formula	C9H10F2O2
Molecular Weight	188.17 g/mol
Synonyms	3-[(2,2-Difluoroethoxy)methyl]phenol (tautomer); 1-(2,2-Difluoroethoxy)-3-(hydroxymethyl)benzene; m-(2,2-Difluoroethoxy)benzyl alcohol; Benzenemethanol, 3-(2,2-difluoroethoxy)-; 3-Hydroxymethylphenyl 2,2-difluoroethyl ether; 2,2-Difluoroethyl 3-(hydroxymethyl)phenyl ether
EINECS	Contact for details

Quality Control

Our 3-(2,2-Difluoroethoxy)Benzyl Alcohol is manufactured under strict quality management systems. We provide material that meets the stringent requirements for pharmaceutical development, supported by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request, ensuring full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.