Description

(R)-4-(3-Amino-3,4-Dihydro-1H-Carbazol-9(2H)-Yl)Butanoic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. This compound matters for its role in the research and development of novel, optically active therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this material for constructing complex molecular architectures where stereochemical integrity is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for targeted cancer therapies and neurological treatments.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the research and scale-up of new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce the (R)-configured stereocenter into more complex molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs in academic and industrial labs.
• Bioconjugation & Probe Development: The carboxylic acid and amino functional groups allow for derivatization to create labeled probes or antibody-drug conjugates (ADCs).
• Process Chemistry & Scale-Up: Used in the development of robust, kilogram-scale synthetic routes for GMP manufacturing.

Basic Information

Product Name	(R)-4-(3-Amino-3,4-Dihydro-1H-Carbazol-9(2H)-Yl)Butanoic Acid
CAS No.	1182722-58-2
Molecular Formula	C20H22N2O2
Molecular Weight	322.40 g/mol
Synonyms	(R)-4-(3-Amino-1,2,3,4-tetrahydrocarbazol-9-yl)butanoic acid; (9R)-4-(3-Amino-3,4-dihydro-1H-carbazol-9(2H)-yl)butanoic acid; (R)-4-(3-Amino-3,4-dihydro-1H-carbazol-9(2H)-yl)butyric acid; (R)-9-(3-Carboxypropyl)-1,2,3,4-tetrahydro-3-amino-9H-carbazole; UNII-1K8Q8KQ2VH; 1K8Q8KQ2VH; (R)-Tetrahydrocarbazolylbutanoic acid derivative; Chiral carbazole amino acid intermediate.
EINECS	Contact for details

Quality Control

Our (R)-4-(3-Amino-3,4-Dihydro-1H-Carbazol-9(2H)-Yl)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and comprehensive identification and assay methods. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.