Description

5-Formylbenzo[B]Thiophen-2-Ylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a boronic acid moiety on a benzothiophene scaffold, makes it an exceptionally versatile reagent for constructing complex molecular architectures. This compound is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, leveraging the benzothiophene core for enhanced biological activity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and organic semiconductors, due to its conjugated system.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs and fine chemical producers specializing in bespoke, high-complexity molecules.

Basic Information

Item	Detail
Product Name	5-Formylbenzo[B]Thiophen-2-Ylboronic Acid
CAS No.	1182272-63-4
Molecular Formula	C9H7BO3S
Molecular Weight	205.03 g/mol
Synonyms	5-Formylbenzo[b]thiophene-2-boronic Acid; 5-Formyl-2-benzothiopheneboronic Acid; 2-Borono-5-formylbenzo[b]thiophene; (5-Formylbenzo[b]thiophen-2-yl)boronic Acid; 5-Formyl-1-benzothiophene-2-boronic Acid; B-(5-Formylbenzo[b]thien-2-yl)boronic Acid; 1182272-63-4
EINECS	Contact for details

Quality Control

Every batch of 5-Formylbenzo[B]Thiophen-2-Ylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), identity (NMR, IR), and moisture content. Our quality protocols are designed to support cGMP and ISO-guided applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.