Description

Asenapine-D3 is a deuterium-labeled analog of the atypical antipsychotic drug asenapine, specifically designed for use as an internal standard in analytical chemistry. This high-purity reference material is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities that require precise and traceable measurements of asenapine in complex biological matrices.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) bioanalytical methods.
• Quantitative analysis of asenapine in pharmacokinetic studies to determine drug concentration in plasma, serum, and other biological fluids.
• Metabolite profiling and drug metabolism studies to investigate the biotransformation pathways of asenapine.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing validated analytical data.
• Quality control and assurance in pharmaceutical manufacturing for the accurate quantification of asenapine in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Use in forensic and clinical toxicology to accurately measure asenapine levels.

Basic Information

Product Name	Asenapine-D3
CAS No.	1180843-72-4
Molecular Formula	C17H13D3ClNO
Molecular Weight	288.78 g/mol
Synonyms	(3aRS,12bRS)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-D3; Asenapine-d3; Asenapine (methyl-d3); Sycrest-D3; Org 5222-D3; SAP-D3; 2-Methyl-5-chloro-3a,12b-dihydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-D3
EINECS	Contact for details

Quality Control

Every batch of Asenapine-D3 is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure compliance with the high-purity standards required for analytical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.