Description

tert-Butyl n-[2-(Trifluoromethyl)-1,3-Thiazol-4-Yl]Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its unique thiazole ring and trifluoromethyl group. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical manufacturers developing next-generation therapeutics, particularly in areas such as oncology and antiviral treatments.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors, leveraging the thiazole moiety for targeted binding.
• Agrochemical Synthesis: Potential intermediate in the development of advanced crop protection agents and pesticides.
• Material Science: Can be investigated as a precursor for specialty polymers or functional materials due to its fluorine content.

Basic Information

Product Name	tert-Butyl n-[2-(Trifluoromethyl)-1,3-Thiazol-4-Yl]Carbamate
CAS No.	1180526-71-9
Molecular Formula	C9H11F3N2O2S
Molecular Weight	268.26 g/mol
Synonyms	Boc-4-Amino-2-(trifluoromethyl)thiazole; tert-Butyl [2-(Trifluoromethyl)-1,3-thiazol-4-yl]carbamate; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-(trifluoromethyl)thiazole; 2-(Trifluoromethyl)-1,3-thiazol-4-amine, N-Boc-protected; N-Boc-2-Trifluoromethyl-4-aminothiazole; 4-(Boc-amino)-2-(trifluoromethyl)thiazole; tert-Butyl (2-(trifluoromethyl)thiazol-4-yl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[2-(Trifluoromethyl)-1,3-Thiazol-4-Yl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate production. Certificates of Analysis (COA) with complete batch data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.