Description

Cyclophosphamide-D8 CAS NO 1178903-96-2 is a deuterated analog of the widely used alkylating agent cyclophosphamide, where eight hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is an essential tool for quantitative bioanalytical research, providing superior accuracy and reliability in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic, metabolic, and clinical studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of cyclophosphamide and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust, regulatory-compliant analytical methods for therapeutic drug monitoring and toxicology studies.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Facilitates precise measurement of drug concentrations in patient samples to optimize dosing regimens and ensure therapeutic efficacy while minimizing toxicity.
• Metabolite Identification and Profiling: Aids in the structural elucidation and quantification of cyclophosphamide metabolites to understand its biotransformation pathways.
• Quality Control in Pharmaceutical Manufacturing: Can be employed as a reference standard in quality control laboratories to ensure the purity and consistency of cyclophosphamide drug substances and products.

Basic Information

Product Name	Cyclophosphamide-D8
CAS No.	1178903-96-2
Molecular Formula	C7H7D8Cl2N2O2P
Molecular Weight	265.13 g/mol
Synonyms	Cyclophosphamide-d8; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide-d8; Deuterated Cyclophosphamide; Cyclophosphamide (D8); N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide-d8; NSC-26271-d8; CP-d8; Endoxan-d8; Cytoxan-d8
EINECS	Contact for details

Quality Control

Our Cyclophosphamide-D8 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and Mass Spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or Certificate of Analysis. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.