Description

1-[(4-Bromo-2-Thienyl)Methyl]Piperazine CAS NO 1177272-46-6 is a high-purity, specialized heterocyclic building block featuring a brominated thiophene moiety linked to a piperazine ring. This compound is of significant value in modern synthetic chemistry, serving as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and advanced materials. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its unique halogenated heterocyclic structure.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of organic semiconductors, conductive polymers, and other advanced electronic materials due to the thiophene component.
• Chemical Biology & Proteomics: Utilized as a building block for designing molecular probes and activity-based protein profiling (ABPP) agents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-fidelity brominated intermediates.

Basic Information

Product Name	1-[(4-Bromo-2-Thienyl)Methyl]Piperazine
CAS No.	1177272-46-6
Molecular Formula	C9H13BrN2S
Molecular Weight	261.18 g/mol
Synonyms	4-Bromo-2-(piperazin-1-ylmethyl)thiophene; 1-[(4-Bromo-2-thienyl)methyl]piperazine; 1-((4-Bromothiophen-2-yl)methyl)piperazine; (4-Bromo-2-thienylmethyl)piperazine; Piperazine, 1-[(4-bromo-2-thienyl)methyl]-; 1177272-46-6; 4-Bromo-2-piperazin-1-ylmethylthiophene
EINECS	Contact for details

Quality Control

Our production of 1-[(4-Bromo-2-Thienyl)Methyl]Piperazine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates. Our quality system is designed to meet the exacting standards of global pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.