Description

2-Hydroxybenzimidazole-D4 is a deuterated derivative of 2-hydroxybenzimidazole, a key heterocyclic compound. This isotopically labeled version is essential for applications requiring high analytical precision and metabolic pathway elucidation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries for use as an internal standard in mass spectrometry and in the development of deuterated active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the quantitative analysis of benzimidazole derivatives in complex biological and environmental matrices.
• Pharmaceutical Research: Used in drug metabolism and pharmacokinetics (DMPK) studies to trace and quantify metabolites, aiding in the development of new therapeutic agents.
• Deuterated API Synthesis: Acts as a building block in the synthesis of deuterium-labeled drugs, which can offer improved metabolic stability and altered pharmacokinetic profiles.
• Analytical Reference Material: Provides a certified standard for method development, validation, and quality control in analytical laboratories.
• Agrochemical Studies: Employed in research on fungicides and pesticides based on the benzimidazole structure to understand environmental fate and degradation pathways.

Basic Information

Product Name	2-Hydroxybenzimidazole-D4
CAS No.	1176802-04-2
Molecular Formula	C7H2D4N2O
Molecular Weight	138.16 g/mol
Synonyms	2-Hydroxy-1H-benzimidazole-d4; 1H-Benzimidazol-2-ol-d4; 2-Benzimidazolol-d4; Deuterated 2-Hydroxybenzimidazole; 2-(Deuteriooxy)benzimidazole-d3; Benzimidazole-2-ol-d4; Isotopically Labeled 2-Hydroxybenzimidazole
EINECS	Contact for details

Quality Control

Our 2-Hydroxybenzimidazole-D4 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and isotopic enrichment, typically exceeding 98% chemical purity and 99% deuterium incorporation. Certificates of Analysis (COA) detailing NMR, HPLC, and MS results are available upon request to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.