Description

5-(Trifluoromethyl)Isoquinolin-3-Ol is a high-value, multi-functional heterocyclic building block characterized by its trifluoromethyl and hydroxyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical candidates and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient isoquinoline core.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on the incorporation and effects of fluorine in organic molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development of scalable synthetic routes.

Basic Information

Product Name	5-(Trifluoromethyl)Isoquinolin-3-Ol
CAS No.	1175271-58-5
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	3-Hydroxy-5-(trifluoromethyl)isoquinoline; 5-(Trifluoromethyl)-3-isoquinolinol; 5-Trifluoromethylisoquinolin-3-ol; 1175271-58-5; 3-Isoquinolinol, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3-hydroxyisoquinoline; 5-Trifluoromethyl-3-hydroxyisoquinoline
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Isoquinolin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.