Description

Dmaba-D4 Nhs Ester CAS NO 1175002-03-5 is a deuterated, amine-reactive chemical reagent primarily used as a labeling agent for proteomics and quantitative mass spectrometry. This compound matters for researchers and manufacturers requiring high-precision, stable isotope-labeled tags for accurate protein quantification and biomarker discovery. It is needed by pharmaceutical R&D teams, contract research organizations (CROs), and diagnostic kit developers working in advanced bioanalytical chemistry and targeted proteomics.

Application

• Quantitative Proteomics: Used as a stable isotope-coded affinity tag for the relative and absolute quantification (iTRAQ/TMT-like workflows) of proteins and peptides in complex biological samples.
• Biomarker Discovery & Validation: Enables precise labeling of amine groups in candidate biomarkers for mass spectrometric analysis in clinical research.
• Pharmaceutical Development: Employed in pharmacokinetic and pharmacodynamic studies to label and track protein-based drug candidates and their metabolites.
• Chemical Biology Research: Serves as a critical reagent for activity-based protein profiling (ABPP) and other chemoproteomic applications to study enzyme function.
• Diagnostic Assay Development: Utilized in the synthesis of internal standards for LC-MS/MS assays to ensure accuracy and reproducibility in clinical diagnostics.
• Post-Translational Modification (PTM) Analysis: Facilitates the study of protein modifications by labeling specific amino acid residues for detailed structural analysis.

Basic Information

Product Name	Dmaba-D4 Nhs Ester
CAS No.	1175002-03-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2,5-Dioxopyrrolidin-1-yl 4-(dimethylamino-d6)benzoate; Dmaba-D4 NHS Ester; Deuterated DMABA NHS Ester; 4-(Dimethyl-d6-amino)benzoic Acid N-Hydroxysuccinimide Ester; N-Succinimidyl 4-(dimethyl-d6-amino)benzoate; DMABA-d4 NHS; DMABA-d4 Active Ester; 4-(N,N-Dimethyl-d6)aminobenzoic Acid NHS Ester
EINECS	Contact for details

Quality Control

Our Dmaba-D4 Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment, and impurity profiles to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.