Description

5-[(4-Aminopiperidin-1-Yl)Methyl]Thiophene-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold that combines a piperidine amine with a thiophene carboxylic acid. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing therapeutics targeting central nervous system (CNS) disorders, oncology, and other specialized disease areas.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for CNS-targeting molecules.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a precursor in the synthesis of compounds designed to inhibit specific protease enzymes.
• Kinase Inhibitor Development: Employed in the construction of heterocyclic cores for potential kinase inhibitor candidates in oncology research.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clinical trials.

Basic Information

Item	Details
Product Name	5-[(4-Aminopiperidin-1-Yl)Methyl]Thiophene-2-Carboxylic Acid
CAS No.	1174863-10-5
Molecular Formula	C11H16N2O2S
Molecular Weight	240.32 g/mol
Synonyms	5-[(4-Aminopiperidin-1-yl)methyl]thiophene-2-carboxylic acid; 2-Thiophenecarboxylic acid, 5-[(4-amino-1-piperidinyl)methyl]-; 5-((4-Aminopiperidin-1-yl)methyl)thiophene-2-carboxylic acid; 1-(2-Carboxythiophen-5-ylmethyl)-4-aminopiperidine; 5-[(4-Amino-1-piperidinyl)methyl]-2-thiophenecarboxylic acid; 5-[(4-Aminopiperidin-1-yl)methyl]-2-thiophenecarboxylic acid; 5-(4-Aminopiperidin-1-ylmethyl)thiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-[(4-Aminopiperidin-1-Yl)Methyl]Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.