Description

5-[(2,2,2-Trifluoroethoxy)Methyl]Thiophene-2-Carboxylic Acid is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is specifically engineered to introduce both a thiophene core and a trifluoroethoxy side chain into target molecules, significantly altering their physicochemical and biological properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, where precise molecular modification is required for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms and heterocyclic structure enhance bioavailability and environmental stability.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of specialty polymers and organic electronic materials, such as conductive polymers or organic light-emitting diodes (OLEDs).
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging the electron-withdrawing trifluoroethoxy group to fine-tune metal center reactivity.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) in medicinal chemistry and for developing new fluorination methodologies.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D pipelines.

Basic Information

Product Name	5-[(2,2,2-Trifluoroethoxy)Methyl]Thiophene-2-Carboxylic Acid
CAS No.	1174851-74-1
Molecular Formula	C9H7F3O3S
Molecular Weight	252.21 g/mol
Synonyms	2-Thiophenecarboxylic acid, 5-[(2,2,2-trifluoroethoxy)methyl]-; 5-[(2,2,2-Trifluoroethoxy)methyl]thiophene-2-carboxylic acid; 5-(Trifluoroethoxymethyl)thiophene-2-carboxylic acid; 2-Carboxy-5-[(2,2,2-trifluoroethoxy)methyl]thiophene; Thiophene-2-carboxylic acid, 5-[(2,2,2-trifluoroethoxy)methyl]-; 1174851-74-1; 5-(2,2,2-Trifluoroethoxymethyl)-2-thiophenecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-[(2,2,2-Trifluoroethoxy)Methyl]Thiophene-2-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our facilities operate under cGMP principles where applicable, ensuring traceability and reliability for our global B2B clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its chemical nature, it is recommended to handle and store this material under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.