Description

Vandetanib-D6 is a deuterated internal standard of the tyrosine kinase inhibitor Vandetanib, specifically designed for use in quantitative analytical methods. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of pharmacokinetic and bioanalytical studies. It is a critical tool for pharmaceutical researchers, analytical laboratories, and quality control departments involved in the development and monitoring of oncology therapeutics.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Vandetanib in biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Studies: Used in metabolite identification and profiling to understand the metabolic pathways of Vandetanib.
• Quality Control & Method Validation: Critical for developing and validating robust analytical methods in pharmaceutical quality control laboratories to ensure batch consistency and purity.
• Clinical Trial Support: Provides reliable data for therapeutic drug monitoring (TDM) and compliance testing during clinical trials of Vandetanib-based treatments.
• Reference Standard: Acts as a certified reference material for calibrating instruments and verifying analytical method performance in compliance with GLP and GMP guidelines.

Basic Information

Product Name	Vandetanib-D6
CAS No.	1174683-49-8
Molecular Formula	C22H18D6ClFN4O2
Molecular Weight	428.91 g/mol (deuterated form)
Synonyms	ZD6474-D6; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine-D6; Vandetanib (hexadeuterated); Vandetanib Internal Standard; Caprelsa-D6 (deuterated); 4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]quinazoline-D6
EINECS	Contact for details

Quality Control

Our Vandetanib-D6 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch undergoes comprehensive analysis, including HPLC for chemical purity and MS for isotopic purity and enrichment. A detailed Certificate of Analysis (COA) is provided, which includes batch-specific data on purity, assay, and solvent residues, supporting compliance with GLP and GMP requirements for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.