Description

Ofloxacin-D3 CAS NO 1173147-91-5 is a deuterium-labeled analog of the broad-spectrum fluoroquinolone antibiotic ofloxacin, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities for drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical trial sample analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of ofloxacin in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used to track and measure the pharmacokinetic profile, bioavailability, and metabolic pathways of the parent drug.
• Bioanalytical Method Development & Validation: Serves as a reference standard to establish robust, sensitive, and reproducible analytical methods compliant with FDA and ICH guidelines.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables accurate measurement of drug concentrations in patient samples during clinical trials and routine TDM.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for ofloxacin-containing drug products.
• Forensic & Anti-Doping Analysis: Employed in confirmatory testing for the presence of fluoroquinolones in forensic toxicology and sports doping control.

Basic Information

Product Name	Ofloxacin-D3
CAS No.	1173147-91-5
Molecular Formula	C18H17D3FN3O4
Molecular Weight	364.37 g/mol (for C18H17D3FN3O4)
Synonyms	Ofloxacin-d3; (±)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl-d3)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; 9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl-d3)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid; DL-8280-d3; Dextrarotation-d3; HOE-280-d3; RU-43280-d3; (RS)-Ofloxacin-D3
EINECS	Contact for details

Quality Control

Our Ofloxacin-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to confirm isotopic purity, chemical purity, and structural identity. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Our quality commitment supports your need for reliable and consistent data in regulated analytical environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.