Description

Robenidine-D8 Hcl is a deuterated analog of the anticoccidial agent Robenidine, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical methods. It is critically needed by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, residue analysis, and quality control for veterinary pharmaceuticals.

Application

• Primary use as an internal standard for the accurate quantification of Robenidine via LC-MS/MS and GC-MS.
• Critical component in pharmacokinetic and bioanalytical studies to determine drug absorption, distribution, metabolism, and excretion.
• Essential for conducting residue testing in animal-derived food products to ensure regulatory compliance and food safety.
• Used in metabolite identification and profiling research to understand drug biotransformation pathways.
• Supports method development and validation in regulatory-compliant analytical laboratories (e.g., following FDA, EMA guidelines).
• Applied in stable isotope dilution analysis to achieve superior precision and accuracy over conventional calibration methods.
• Valuable for quality control and assurance in the manufacturing of veterinary medicinal products containing Robenidine.

Basic Information

Product Name	Robenidine-D8 Hcl
CAS No.	1173097-77-2
Molecular Formula	C₁₅H₅D₈Cl₃N₄ • HCl
Molecular Weight	428.16 g/mol (approx.)
Synonyms	1,3-Bis[(4-chlorobenzylidene)amino]guanidine-D8 Hydrochloride; Robenidine-d8 Hydrochloride; Deuterated Robenidine HCl; Robenidine (phenyl-d5, benzyl-d3) Hydrochloride; N,N'-Bis(4-chlorobenzylidene)diaminomethanediimidium-d8 Chloride; Robenidine Internal Standard; Stable Isotope Labeled Robenidine HCl; Robenz-D8 HCl
EINECS	Contact for details

Quality Control

Every batch of Robenidine-D8 Hcl is manufactured and analyzed under strict quality systems to ensure exceptional isotopic purity and chemical integrity, which are paramount for its use as an analytical standard. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm deuteration level and chemical purity, ensuring compliance with industry standards. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific analytical results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere conditions to maintain stability and isotopic purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected m/z
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration Degree)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.