Description

n-Desethyl Amodiaquine-D5 is a deuterated internal standard critical for ensuring analytical accuracy in quantitative mass spectrometry. This high-purity compound is essential for researchers and quality control laboratories requiring precise and reliable measurements of its non-deuterated counterpart. It is primarily utilized in pharmaceutical research, metabolism studies, and bioanalytical method development for antimalarial drugs.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, isotopically labeled reference compound for the accurate quantification of amodiaquine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: A key component in establishing robust, sensitive, and specific analytical methods compliant with regulatory guidelines (e.g., FDA, EMA).
• Drug Impurity Profiling: Used as a reference marker in the identification and quantification of desethyl amodiaquine-related impurities in active pharmaceutical ingredient (API) batches.
• Forensic and Toxicological Analysis: Supports the accurate determination of amodiaquine concentrations in forensic investigations and toxicology reports.

Basic Information

Item	Detail
Product Name	n-Desethyl Amodiaquine-D5
CAS No.	1173023-19-2
Molecular Formula	C20H17D5ClN3O
Molecular Weight	355.88 g/mol (approx.)
Synonyms	4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethyl-d5)amino]phenol; Desethylamodiaquine-d5; 2-[(Diethyl-d5)amino]-4-[(7-chloroquinolin-4-yl)amino]phenol; N-Desethyl Amodiaquine D5; Amodiaquine N-Desethyl D5; AQ-d5 Metabolite; Deuterated Desethyl Amodiaquine
EINECS	Contact for details

Quality Control

Our n-Desethyl Amodiaquine-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by comprehensive analytical data, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.