Description

α-Ketoglutaric Acid-D6, also known as α-Ketopentanoic Acid-D6, is a high-purity, deuterium-labeled isotopologue of α-ketoglutaric acid, a key intermediate in the Krebs cycle. This stable isotope-labeled compound is essential for advanced analytical and research applications where precise metabolic tracing and quantification are required. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors for applications in mass spectrometry, NMR spectroscopy, and metabolic pathway studies.

Application

• Internal Standard for LC-MS/MS and GC-MS Analysis: Serves as a critical quantitative reference standard in bioanalytical methods for measuring endogenous α-ketoglutarate levels in biological fluids and tissue samples.
• Metabolic Flux Analysis (MFA): Used as a tracer to study the dynamics of central carbon metabolism, including the TCA cycle, in cell cultures, tissues, and whole organisms.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Employed in stable isotope labeling studies to investigate the metabolic fate of pharmaceutical compounds.
• Biochemical Research: A vital tool for enzymatic assays and studies involving 2-oxoglutarate-dependent dioxygenases, such as prolyl hydroxylases and histone demethylases.
• Nutraceutical and Clinical Research: Supports research into the role of α-ketoglutarate in cellular energy production, amino acid synthesis, and its potential therapeutic applications.

Basic Information

Item	Detail
Product Name	α-Ketoglutaric Acid-D6, α-Ketopentanoic Acid-D6
CAS No.	1173021-86-7
Molecular Formula	C5H2D6O5
Molecular Weight	150.15 g/mol
Synonyms	2-Oxoglutaric Acid-d6; 2-Oxopentanedioic Acid-d6; α-Ketoglutaric Acid-d6; AKG-d6; 2-Ketoglutaric Acid-d6; 2-Ketopentanedioic Acid-d6; Oxoglutaric Acid-d6; Deutero-labeled α-Ketoglutarate
EINECS	Contact for details

Quality Control

Every batch of α-Ketoglutaric Acid-D6 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and isotopic enrichment meet the highest standards for research use. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for isotopic purity (D-enrichment), chemical purity (by HPLC), and specific identification tests. Our quality commitment supports compliance with the rigorous demands of analytical and regulatory science.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.