Description

1-(4-Fluorophenyl-D4)-4-(4-(2-Pyridinyl)-1-Piperazinyl)-1-Butanone, 4'-Fluoro-4-[4-(2-Pyridyl)-1-Piperazinyl]Butyrophenone-D4 CAS NO 1173021-72-1 is a deuterated derivative of a butyrophenone-based compound, serving as a critical stable isotope-labeled internal standard for analytical research. This high-purity compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry, eliminating variability from isotopic effects. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in method development, pharmacokinetic studies, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled reference standard for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioanalytical Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Profiling and Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based assays.
• Method Development and Validation: Critical for developing robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and stability testing of active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic and Doping Control Analysis: Provides a reliable reference for confirmatory testing in forensic toxicology and anti-doping programs.

Basic Information

Product Name	1-(4-Fluorophenyl-D4)-4-(4-(2-Pyridinyl)-1-Piperazinyl)-1-Butanone, 4'-Fluoro-4-[4-(2-Pyridyl)-1-Piperazinyl]Butyrophenone-D4
CAS No.	1173021-72-1
Molecular Formula	C19H18D4FN3O
Molecular Weight	327.42 g/mol
Synonyms	4'-Fluoro-4-[4-(2-pyridinyl)-1-piperazinyl]butyrophenone-d4; 1-(4-Fluorophenyl-d4)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone; 4'-Fluoro-4-(4-pyridin-2-ylpiperazin-1-yl)butyrophenone-d4; Deuterated 4'-Fluoro-4-(4-(2-pyridyl)piperazino)butyrophenone; 4-FPB-d4; 4'-Fluorobutyphenone-d4 (deuterated analog); 1-Butanone, 1-(4-fluorophenyl-d4)-4-[4-(2-pyridinyl)-1-piperazinyl]-; 4'-Fluoro-4-(4-(pyridin-2-yl)piperazin-1-yl)butyrophenone-d4
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment verified by advanced analytical techniques including NMR (1H, 13C) and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic purity (D-enrichment), and analytical results. Our quality commitment aligns with the standards expected for GMP/GLP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, storing desiccated at -20°C is recommended.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.