Description

Carazolol D7 is a deuterated analog of the β-adrenergic receptor antagonist Carazolol, specifically labeled with seven deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of Carazolol in complex biological matrices using advanced analytical techniques. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of Carazolol in plasma, serum, urine, and tissue homogenates.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Method Development and Validation: Used as a reference material to develop, optimize, and validate robust and regulatory-compliant bioanalytical assays.
• Doping Control and Forensic Analysis: Supports accurate detection and confirmation of Carazolol in sports doping control and forensic toxicology investigations.
• Stable Isotope Dilution Assays: Fundamental for high-precision assays where minimizing variability and correcting for sample preparation losses is paramount.
• Quality Control in Reference Material Production: Acts as a calibrant or control in the production and certification of Carazolol reference standards.

Basic Information

Product Name	Carazolol D7
CAS No.	1173021-02-7
Molecular Formula	C18H15D7N2O2
Molecular Weight	~301.4 g/mol
Synonyms	1-(Carbazol-4-yloxy)-3-[(1,1-dimethylethyl)amino]-2-propanol-d7; 4-[2-Hydroxy-3-[(1,1-dimethylethyl)amino]propoxy]carbazole-d7; Carazolol-d7; Carbazolol D7; Deuteron Carazolol; [2H7]-Carazolol; BM 51052 D7; Suacron D7
EINECS	Contact for details

Quality Control

Our Carazolol D7 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (Nuclear Magnetic Resonance) and Mass Spectrometry to confirm isotopic enrichment and chemical purity, as well as HPLC for chromatographic purity assessment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic purity, and solvent content, ensuring traceability and compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be kept under dry, inert conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.