Description

(±)-Nicotine-D3 CAS NO 1173021-00-5 is a deuterium-labeled isotopologue of nicotine, a potent alkaloid, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative analytical methods, ensuring unparalleled accuracy and reliability in trace-level detection. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic, and toxicology sectors who require precise measurement of nicotine and its metabolites.

Application

• Internal Standard for LC-MS/MS and GC-MS Analysis: Primary application for the accurate quantification of nicotine, cotinine, and other metabolites in complex biological matrices.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of nicotine absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Forensic Toxicology: Used in the definitive analysis of nicotine levels in forensic investigations, providing legally defensible data.
• Tobacco and E-cigarette Research: Critical for studying nicotine delivery, exposure assessment, and the development of reduced-risk products.
• Quality Control in Pharmaceutical Development: Ensures batch-to-batch consistency and purity assessment in the development of nicotine replacement therapies (NRTs).
• Environmental and Occupational Exposure Monitoring: Facilitates the sensitive detection of nicotine in environmental samples and workplace air.

Basic Information

Product Name	(±)-Nicotine-D3
CAS No.	1173021-00-5
Molecular Formula	C₁₀H₁₁D₃N₂
Molecular Weight	165.24 g/mol
Synonyms	Nicotine-d3; (RS)-Nicotine-d3; 3-[(2S)-1-Methyl-2-pyrrolidinyl]pyridine-d3; dl-Nicotine-d3; Nicotine (methyl-d3); (±)-3-(1-Methyl-2-pyrrolidinyl)pyridine-d3; Nicotine Internal Standard; Nicotine-d3 Isotopic Standard
EINECS	Contact for details

Quality Control

Our (±)-Nicotine-D3 is manufactured under strict quality protocols to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic purity (by MS), and chemical purity. We adhere to relevant industry standards for reference materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. Due to its hygroscopic and highly volatile nature, the container should be allowed to reach room temperature before opening to minimize moisture ingress and loss of material. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (chemical purity)
Isotopic Purity (MS)	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.