Description

Spermidine-[D8].3HCl is a high-purity, deuterium-labeled isotopologue of spermidine trihydrochloride, a critical polyamine essential for cellular growth and function. This stable isotope-labeled compound is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical workflows. It is an indispensable tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors, enabling precise quantification of endogenous spermidine levels in complex biological matrices.

Application

• Quantitative Mass Spectrometry (MS) & LC-MS/MS: Serves as a critical internal standard for the accurate and sensitive quantification of endogenous spermidine in pharmacokinetic, metabolomic, and biomarker discovery studies.
• Biomedical & Clinical Research: Used in research focused on aging, autophagy, cellular stress response, and diseases where polyamine metabolism is dysregulated, such as cancer and neurodegenerative disorders.
• Drug Discovery & Development: Facilitates the analysis of drug candidates that interact with polyamine pathways, supporting ADME (Absorption, Distribution, Metabolism, Excretion) studies and bioanalytical method validation.
• Nutritional & Food Science Analysis: Enables precise measurement of spermidine content in food products, dietary supplements, and nutraceuticals for quality control and labeling verification.
• Metabolomics & Systems Biology: Provides a stable isotope reference for mapping polyamine flux and understanding metabolic networks in cell cultures, tissues, and biofluids.
• Quality Control & Reference Standards: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating testing methods in GMP/GLP-compliant laboratories.

Basic Information

Product Name	Spermidine-[D8].3HCl
CAS No.	1173019-26-5
Molecular Formula	C7H11D8N3·3HCl
Molecular Weight	291.70 g/mol (for free base C7H11D8N3)
Synonyms	N-(3-Aminopropyl)-1,4-butanediamine-1,1,2,2,3,3,4,4-D8 trihydrochloride; Spermidine-D8 trihydrochloride; Deuterated Spermidine trihydrochloride; [D8]-Spermidine·3HCl; 1,5,10-Triazadecane-1,1,2,2,3,3,4,4-D8 trihydrochloride; N-(3-Aminopropyl)butane-1,4-diamine-D8 trihydrochloride; Polyamine Internal Standard
EINECS	Contact for details

Quality Control

Our Spermidine-[D8].3HCl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing all specification results, ensuring traceability and compliance with research and quality control requirements. Specifications are tailored to meet the needs of analytical and pharmaceutical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.