Description

Phthalic-13C6 Anhydride is a stable isotope-labeled analog of phthalic anhydride, where all six carbon atoms in the aromatic ring are the carbon-13 (13C) isotope. This compound is essential as a high-purity internal standard and tracer in quantitative mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, providing unmatched accuracy for analytical method development and validation. It is critically needed by research laboratories, pharmaceutical developers, and environmental testing facilities engaged in metabolomics, pharmacokinetic studies, polymer analysis, and the synthesis of labeled compounds for precise quantification.

Application

• Internal Standard for Quantitative MS/MS Analysis: Used as a certified reference material for the accurate quantification of phthalic anhydride and related metabolites or degradation products in complex biological and environmental matrices.
• Metabolic Pathway Tracing: Serves as a 13C-labeled precursor in metabolic flux studies to track the incorporation and transformation of phthalate derivatives in biological systems.
• Polymer Chemistry Research: Employed in the synthesis of 13C-labeled polymers, such as alkyd resins and polyesters, for advanced material characterization, degradation studies, and NMR structural analysis.
• Pharmaceutical Impurity Profiling: Critical for developing and validating sensitive LC-MS methods to identify, characterize, and quantify genotoxic impurities (GTIs) like phthalic anhydride in active pharmaceutical ingredients (APIs).
• Environmental Analysis: Acts as a tracer in method development for detecting phthalate-based plasticizer degradation products in water, soil, and air samples.
• Synthesis of Labeled Compounds: A key building block for the preparation of other 13C-labeled fine chemicals, dyes, and pharmaceutical intermediates requiring isotopic labeling.

Basic Information

Product Name	Phthalic-13C6 Anhydride
CAS No.	1173019-01-6
Molecular Formula	13C6C2H2O3 or C813C6H2O3
Molecular Weight	~158.10 g/mol (for 13C6)
Synonyms	1,3-Isobenzofurandione-13C6; Phthalic Anhydride-13C6; 13C6-Phthalic Anhydride; Isotopically Labeled Phthalic Anhydride; Benzene-1,2-dicarboxylic Anhydride-13C6; PA-13C6; 1,2-Benzenedicarboxylic Anhydride-13C6
EINECS	Contact for details

Quality Control

Every batch of Phthalic-13C6 Anhydride is manufactured and analyzed under strict quality systems to ensure exceptional isotopic and chemical purity, critical for trace-level analytical applications. Our products undergo rigorous quality testing, including isotopic enrichment verification by NMR and MS, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for isotopic purity, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under dry, inert conditions (e.g., under argon or nitrogen) in a cool, dry place (15-25°C). Keep the container tightly sealed when not in use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Isotopic Purity (13C)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99% 13C6
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.