Description

2-Keto-3-Methylbutyric Acid-13C5 Sodium Salt is a stable, isotopically labeled sodium salt form of a key branched-chain keto acid. This compound is essential as a high-purity internal standard and tracer in quantitative mass spectrometry-based metabolomics and proteomics research. It is primarily utilized by analytical laboratories, pharmaceutical R&D departments, and academic institutions engaged in metabolic pathway analysis, biomarker discovery, and drug metabolism studies.

Application

• Mass Spectrometry Internal Standard: Used for the precise quantification of endogenous 2-keto-3-methylbutyric acid and related metabolites in biological samples via LC-MS/MS and GC-MS.
• Metabolic Flux Analysis (MFA): Serves as a 13C-labeled tracer to study the dynamics of branched-chain amino acid (valine) catabolism and related pathways in cell cultures, tissues, or whole organisms.
• Biomarker Research: Enables accurate measurement of metabolite level alterations associated with metabolic disorders, such as maple syrup urine disease (MSUD).
• Pharmaceutical Development: Employed in pharmacokinetic and drug metabolism studies to track the fate of drug compounds and their interaction with metabolic networks.
• Nutritional Science: Used in research investigating protein metabolism, amino acid utilization, and energy homeostasis.
• Quality Control Reference: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating assay methods in diagnostic and contract research organizations (CROs).

Basic Information

Product Name	2-Keto-3-Methylbutyric Acid-13C5 Sodium Salt
CAS No.	1173018-24-0
Molecular Formula	13C5H7NaO3
Molecular Weight	Contact for details
Synonyms	2-Oxoisovaleric Acid-13C5 Sodium Salt; 3-Methyl-2-oxobutyric Acid-13C5 Sodium Salt; α-Ketoisovaleric Acid-13C5 Sodium Salt; KIV-13C5 Sodium Salt; Sodium 2-Keto-3-Methylbutanoate-13C5; Sodium 3-Methyl-2-oxobutanoate-13C5; Sodium α-Ketoisovalerate-13C5; 2-Ketoisovalerate-13C5 Sodium Salt
EINECS	Contact for details

Quality Control

Our 2-Keto-3-Methylbutyric Acid-13C5 Sodium Salt is manufactured under strict quality systems to ensure the high isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (≥99 atom % 13C), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.