Description

3-Hydroxy-Tetrahydro-Thiophene-3-Carboxylic Acid is a versatile sulfur-containing heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique structural motif, which combines a tetrahydrothiophene ring with both hydroxyl and carboxylic acid functional groups, enabling its use in constructing complex molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications such as drug discovery, process chemistry, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting enzymes or receptors where the thiophene scaffold is relevant.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the sulfur heterocycle can contribute to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis, leveraging its multiple functional handles for modification.
• Material Science Research: Investigated as a monomer or building block for specialty polymers and functional materials with potential electronic or binding properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tool compounds for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific heterocyclic scaffold.

Basic Information

Product Name	3-Hydroxy-Tetrahydro-Thiophene-3-Carboxylic Acid
CAS No.	1172851-82-9
Molecular Formula	C6H10O3S
Molecular Weight	162.21 g/mol
Synonyms	3-Hydroxytetrahydrothiophene-3-carboxylic acid; Tetrahydro-3-hydroxy-3-thiophenecarboxylic acid; 3-Thiophenecarboxylic acid, tetrahydro-3-hydroxy-; 3-Hydroxy-tetrahydro-thiophene-3-carboxylic acid; 3-Carboxy-3-hydroxytetrahydrothiophene; 3-Hydroxythiolane-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-Tetrahydro-Thiophene-3-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.