Description

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-amino-, hydrochloride is a high-value, structurally constrained bicyclic building block with a rigid, three-dimensional scaffold. This compound matters for its unique ability to impart improved metabolic stability, solubility, and potency in drug discovery, serving as a bioisostere for para-substituted benzene rings or tert-butyl groups. It is primarily needed by pharmaceutical and agrochemical R&D teams for synthesizing novel active ingredients, as well as by advanced material scientists exploring novel polymers and ligands.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small molecule therapeutics, particularly in oncology and CNS drug discovery.
• Bioisostere in Medicinal Chemistry: Used to replace planar aromatic rings or bulky aliphatic groups to optimize ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) properties of lead compounds.
• Agrochemical Research: Intermediate for developing new generation pesticides and herbicides with enhanced efficacy and environmental profile.
• Peptide Mimetics & Conjugation: Serves as a rigid, non-natural amino acid analog for constructing conformationally restricted peptides or for bioconjugation strategies.
• Material Science & Polymer Chemistry: Monomer for creating polymers with unique thermal and mechanical properties due to its strained, cage-like structure.
• Ligand Synthesis for Catalysis: Precursor for synthesizing specialized phosphine or nitrogen-donor ligands used in asymmetric catalysis.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-amino-, hydrochloride
CAS No.	1172097-47-0
Molecular Formula	C7H12ClNO2
Molecular Weight	177.63 g/mol
Synonyms	3-Aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride; 1-Carboxy-3-aminobicyclo[1.1.1]pentane hydrochloride; 3-Amino-BCP-COOH·HCl; 3-Aminobicyclo[1.1.1]pentyl-1-carboxylic acid HCl; BCP-NH2-COOH hydrochloride; (3-Aminobicyclo[1.1.1]pentan-1-yl)formic acid hydrochloride; 3-Amino-1-carboxybicyclo[1.1.1]pentane HCl salt
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-amino-, hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.