Description

2,3-Dimethoxy-6-((trimethylsilyl)ethynyl)pyridine is a specialized organosilicon building block featuring a pyridine core functionalized with methoxy groups and a trimethylsilyl-protected alkyne. This compound matters for its role as a key synthetic intermediate in advanced organic synthesis, particularly in cross-coupling reactions like Sonogashira coupling. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex molecules, including active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those requiring functionalized pyridine or alkyne moieties.
• Ligand Synthesis: Used in the preparation of sophisticated ligands for catalysis and materials science applications.
• Organic Electronic Materials: Serves as a precursor in the development of conjugated polymers and small molecules for OLEDs and other optoelectronic devices.
• Agrochemical Research: Employed in the discovery and synthesis of new active ingredients with enhanced properties.
• Cross-Coupling Reactions: The protected alkyne group makes it a valuable substrate in Sonogashira and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological systems due to its reactive handle.

Basic Information

Product Name	2,3-Dimethoxy-6-((trimethylsilyl)ethynyl)pyridine
CAS No.	1171919-83-7
Molecular Formula	C₁₂H₁₇NO₂Si
Molecular Weight	235.36 g/mol
Synonyms	6-((Trimethylsilyl)ethynyl)-2,3-dimethoxypyridine; 2,3-Dimethoxy-6-(2-trimethylsilylethynyl)pyridine; Pyridine, 6-[(trimethylsilyl)ethynyl]-2,3-dimethoxy-; TMS-Ethynyl-2,3-dimethoxypyridine
EINECS	Contact for details

Quality Control

Our 2,3-Dimethoxy-6-((trimethylsilyl)ethynyl)pyridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.