Description

3-Iodo-5-Methoxy-6-(Trifluoromethyl)-1H-Indole is a high-value, multi-functional indole derivative, distinguished by its unique trifluoromethyl and iodo substituents. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in modern synthetic chemistry, enabling the development of novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate halogenated, fluorinated motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in creating novel pesticides and herbicides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized organic semiconductors and photoactive materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Building Block: Essential for introducing the pharmacologically beneficial trifluoromethyl group into target molecules.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and novel synthetic route exploration.

Basic Information

Product Name	3-Iodo-5-Methoxy-6-(Trifluoromethyl)-1H-Indole
CAS No.	1171918-93-6
Molecular Formula	C10H7F3INO
Molecular Weight	341.07 g/mol
Synonyms	6-(Trifluoromethyl)-5-methoxy-3-iodo-1H-indole; 5-Methoxy-6-(trifluoromethyl)-3-iodoindole; 3-Iodo-5-methoxy-6-trifluoromethylindole; 1H-Indole, 3-iodo-5-methoxy-6-(trifluoromethyl)-; 1171918-93-6
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-5-Methoxy-6-(Trifluoromethyl)-1H-Indole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process chemistry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.