Description

1-(tert-Butyl) 5-Methyl 3-(2-Aminoethyl)-1H-Indole-1,5-Dicarboxylate Hydrochloride is a high-purity, protected indole derivative of significant importance in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Peptidomimetic Research: Serves as a constrained scaffold or side-chain component in the design of peptide analogs and mimetics.
• Medicinal Chemistry: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Intermediate in the development of advanced crop protection agents and plant growth regulators.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and probes for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific molecules under cGMP or research-grade conditions.

Basic Information

Product Name	1-(tert-Butyl) 5-Methyl 3-(2-Aminoethyl)-1H-Indole-1,5-Dicarboxylate Hydrochloride
CAS No.	1171456-52-2
Molecular Formula	C17H22N2O4 • HCl
Molecular Weight	354.83 g/mol (Free base: 318.37 g/mol)
Synonyms	tert-Butyl 5-Methyl 3-(2-Aminoethyl)-1H-indole-1,5-dicarboxylate Hydrochloride; 3-(2-Aminoethyl)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-1H-indole Hydrochloride; 1-Boc-5-Methyl 3-(2-Aminoethyl)indole-1,5-dicarboxylate HCl; 1-(tert-Butoxycarbonyl)-5-(methoxycarbonyl)-3-(2-aminoethyl)indole Hydrochloride; 3-(2-Aminoethyl)-1H-indole-1,5-dicarboxylic acid 1-tert-butyl 5-methyl ester hydrochloride; N-Boc-3-(2-Aminoethyl)-5-methoxycarbonylindole Hydrochloride; Protected 3-(2-Aminoethyl)indole Derivative HCl Salt
EINECS	Contact for details

Quality Control

Our production of 1-(tert-Butyl) 5-Methyl 3-(2-Aminoethyl)-1H-Indole-1,5-Dicarboxylate Hydrochloride adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for critical synthesis workflows. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development and commercial projects with material suitable for research use, process development, and can discuss cGMP-grade manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.